I Am Legend (2007)
Loosely based on the 1954 novel of the same name by Richard Matheson, I Am Legend is set in 2012 New York City where a man-made virus, originally created to cure cancer, has transformed most humans into bloodthirsty mutants. It follows U.S. Army virologist Robert Neville (Will Smith) as he calls out for other possible survivors and works on finding a cure for the plague using his own immune blood.
While I Am Legend was criticized for its questionable special effects and divergences from the source material, particularly the ending, Smith was praised by critics for its top-notch performance in the Francis Lawrence-directed film.