I Am Legend (2007)
Loosely based on the 1954 novel of the same name by Richard Matheson, I Am Legend is set in 2012 New York City after a man-made virus, originally created to cure cancer, has transformed most humans into bloodthirsty mutants. It follows U.S. Army virologist Robert Neville (Will Smith) as he calls out for other possible survivors and works on finding a cure for the plague using his own immune blood.
Though the plague depicted in the Francis Lawrence-directed movie can be compared to the ongoing COVID-19 pandemic, the latter didn’t begin until the end of 2019. And while over 3 million people have already died from COVID, people who contract the virus don’t turn into bloodthirsty mutants.